Jennifer Aniston gained worldwide fame for playing Rachel Green in the popular television sitcom Friends, a role that earned her an Emmy Award, a Golden Globe and a Screen Actors Guild Award. The character was hugely popular during the series' run, resulting in her being recognized as one of the 100 Greatest Female TV Characters in the United States.

She is the co-founder, in 2008, of the production company Echo Films. She is one of the highest paid actresses in Hollywood and was ranked the 11th richest woman in the entertainment industry in 2007, with an estimated fortune of $110 million.

She revealed that she was dyslexic, which impacted her education and self-esteem. This diagnosis, received as a twenty-year-old, changed the actress's way of looking at her own life. She stated: "I thought I wasn't smart. I couldn't learn anything. And then I made this big discovery, and it was like all my childhood traumas were explained away and resolved."

She had an affair with actor Tate Donovan. The couple began dating in 1995, and ended their relationship two and a half years later, in 1998. Jennifer met Brad Pitt in 1998; their relationship was highly publicized in the media. After almost three years of relationship, on July 29, 2000 she marries the actor in a sumptuous ceremony in Malibu. For a few years, their union was considered one of the rare successes in the Hollywood environment. On January 7, 2005, the two announced their separation, and then divorced on October 2 of the same year. In 2011 she became engaged to Justin Theroux, with whom she married on August 5, 2015 in her private residence in Beverly Hills. On February 16, 2018, Aniston announces her separation from her husband after 2 and a half years of marriage.