A recent study found that one of the most commonly prescribed drugs to treat type 2 diabetes, metformin, was associated with a 1.4-fold higher risk of developing birth defects in boys taking the drug The Danish scientists have found that one of the most commonly prescribed diabetes drugs in the world could be linked to more severe birth defects in the offspring of male patients who were prescribed the drug before conception, according to a new study by them.
According to scientists from the University of Southern Denmark and the American Stanford University, the use of metformin, one of the most commonly prescribed diabetes medications, is associated with a 1.4 times higher risk of developing birth defects in boys whose fathers take the drug compared to those whose fathers do not take the drug as therapy.
There was no history of diabetes or hypertension in either group of mothers. In spite of this, there are several key limitations that have been highlighted by the authors of the study, as well as independent experts, in the journal Annals of Internal Medicine, which published the results of the study.
The researchers wanted to know whether the fathers took their medications as prescribed or whether they were less careful in managing their diabetes, which might also be associated with a higher risk of birth defects if the fathers didn't take their medications as prescribed.
Additionally, it showed that there was no increased risk for babies whose fathers took insulin instead of metformin in the study. According to Channa Jayasena, head of andrology at Imperial College London, who was not involved in the research, the results were challenging, warranting further investigation, but insufficiently convincing to justify further study." "Men with diabetes should not be dissuaded from taking metformin under any circumstances, but the results should be studied in more detail," he said.
This drug, also available under the brand name Metformin, is one of the most effective treatments available for the treatment of type 2 diabetes, which is a disease that is gaining epidemic proportions across the globe.